Mon-Sat: 8:00 am - 10:00 pm ยท Sun: 8:00 am - 7:00 pm

Your local San Antonio River Center Drug Store

Welcome to River Center Drug Store, your one stop for drug store necessities and gifts in the downtown area. Conveniently located in River Center Mall, near the Marriot Hotel mall entrance on street level. Our store features a variety of snacks, candy, drinks, as well as a wide range of unique gifts and San Antonio Souvenirs.



We got you covered!

River Center Drug store features a huge selection of beer and wine. We take pride in the unique selection of Texas Craft beers and wide range of champagne and wine. We offer all of your necessary accessories, like koozies, wine openers, coolers, and bags of ice. Be sure to check our specialty gifts that perfectly compliment your beer and wine selection. Souvenir San Antonio and Texas pint glasses, shot glasses, and wine bottle holders. We got you covered!

We have your Essentials!

Our store offers all the drug store essentials you need in the downtown San Antonio area. You can find everything from toothpaste and toothbrushes to facial care, allergy and pain medication and much more! We carry most over the counter drug store medications and a large selection of toiletries items. Find everything you need and more at River Center Drug Store!